Why do some people get out of the predicament of life, while others are put on depression? A new study shows that a certain gene can explain this difference between people. Researchers who have experienced highly-stressed life events have found that people who have mutated brain chemicals whose gene name is galanin are more likely to have depression than people with similar experience and normal galanin.
Galanin is a peptide that is widely present in the human nervous system and is thought to have effects in regulating pain, waking and sleep, feeding, blood pressure, and mood. A very small number of studies have shown that galanin has an effect of causing tension and anxiety. This finding shows that the brain's galanin system makes people more susceptible to psychological stress and has a significant role in the development of depression. Researchers published their study in a journal article of the National Academy of Sciences on March 24. . In this study, the researchers also found that the galanin system had the greatest impact on the development of depression in the most stressful life. People who have genetic mutations in galanin have already received a higher risk of depression, and those who have experienced less stressful life are better than those who have been living in tension. This study also proves that the interaction between the environment and the genes is more powerful than the individual genes or the environment.
In this study, the researchers found that the effects of galanin system genes were stronger than those of serotonin gene mutations. It is not clear how the galanin system causes depression, the researchers said, but the new results suggest that exploration of the galanin system should be the goal of developing new antidepressants.
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